I'll begin with the Battelle Rencontre "Lectures in Mathematics and Physics" (Seattle, 1967) and end with S-duality as reflected in Mirror Symmetry and in the Electric-Magnetic Duality connection with the Geometric Langlands Program. In between will be a guided tour of special moments in the interaction of mathematicians and high energy theorists: gauge theory and fibre bundles, instantons and index theory, string theory and Calabi-Yau manifolds.